1Jaipur College of Pharmacy, Jaipur-302022
2Department of Pharmaceutical Sciences, Choudhary Bansilal University, Bhiwani-127021
3Delhi Pharmaceutical Sciences and Research University, New Delhi, Delhi-110017
4MM College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullan, Ambala-133207
*Corresponding Author E-mail: tanujhooda2010@gmail.com
Online published on 6 May, 2025.
The leaves of Saraca asoca (the Ashoka tree), a member of Caesalpinioideae family, have been used widely in Traditional medicines; however, their wound healing ability in diabetic condition is not investigated yet. The aim of present study was to investigate the anti-diabetic and wound healing potential of Saraca asoca leaves extract in various streptozocin induces diabetic animal models.
Antidiabetics activity was evaluated in streptozocin induced rat models and wound healing potential was determined using excision and incision wound models.
The aqueous and ethanolic extracts induced hypoglycemia and improved glucose tolerance in normal rats, despite the presence of counter-regulatory mechanisms aimed at preventing a decrease in blood glucose levels. This suggests that the hypoglycemic action of the aqueous and ethanolic extracts may be attributed to extra-pancreatic processes or by stimulating the remaining cells to produce more insulin.
The present study suggests that the extracts of Saraca asoca leave have significant anti-diabetic and wound healing potential.
Saraca asoca, Plant extract, Anti-diabetic activity, Wound healing activity, Animal models
