Synthesis and identification of a novel N-mannich base from isatin using a sonicator by adding DCM as catalyst

Isatin represents a derivative of indole heterocycles characterized by the presence of a ketone group and a secondary amide group. Its fundamental characteristics encompass the inclusion of a lactam group and a ketone group within the indole nucleus. These distinctive functional groups have prompted extensive academic research on this compound. Isatin assumes a pivotal role in the synthesis of numerous compounds through a large number of chemical reactions, the most important of them the Schiff base reaction, yielding the carbon atom at position No. 3, and the Mannich base reaction, acquiring the nitrogen atom. The latter has been synthesized in an unconventional method within the scope of this study, demonstrating a relatively expeditious process that involves relatively short time and yielding moderate, facilitated by the utilization of dichloromethane (DCM) as a catalyst in the presense of a sonicator device.