1Chettinad School of Pharmaceutical Sciences, Chettinad Hospital and Research Institute, Chettinad Academy of Research and Education, Kelambakkam - 603103, Tamilnadu, India
2Department of Pharmacy, Central University of South Bihar, Gaya-824236, Bihar, India
*Corresponding Author E-mail: devit@care.edu.in
Online published on 6 May, 2025.
This study investigates the use of lipid polysaccharide hybrid nanoparticles (LPHNPs) as a drug delivery vehicle for Vildagliptin. The researchers used a nanoprecipitation strategy with PLGA and soybean phosphatidylcholine to create stacked LPHNPs. The study discovered that the nanosized and round LPHNPs had a similar size distribution and significantly improved drug absorption and dissolution in the crossbreed network. The content of polymer led to a rise in the size of the nanoparticles, while the content of lipid and polymer enhanced the efficacy of drug entrapment. The in vitro drug release ranged from 72-94%, and the delivery components followed the Korsmeyer-Peppas model and Fickian diffusion. The study suggests that PLGA and soybean phosphatidylcholine-based framework LPHNPs could be promising for improving Vildagliptin dissolution and increasing its profile accessibility.
Vildagliptin, Polymeric nanoparticles, Liposomes, Lipid polymer hybrid nanoparticles, PLGA
