1MD Pathology, Assistant Professor, Department of Pathology, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India
2MD Pathology, Assistant Professor, Department of Pathology, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India
3MD Pathology, Assistant Professor, Department of Pathology, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India
4MD Pathology, Assistant Professor, Department of Pathology, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India
5MD Medicine, Professor, Department of Geriatric Medicine, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India
6MD Pathology, Professor & Head , Department of Pathology, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India
*Address for communication- Department of Pathology, Institute of Medical Sciences (IMS), Banaras Hindu University (BHU), Varanasi, Uttar Pradesh, India, Corresponding Author e-mail: anusingh@bhu.ac.in
Online published on 6 May, 2025.
Role of anti-neutrophil cytoplasmic antibodies (ANCA) in pathogenesis of systemic lupus erythematous (SLE) and its association with clinical manifestations is not completely understood. Prevalence data of ANCA in SLE patients of Indian population is limited.
The aim of the present study is to measure the prevalence of ANCAs in SLE patients and study its association with clinical manifestations of SLE.
Total 92 patients of SLE cases were included in this prospective observational study. Demographic, clinical and laboratory data was collected in all patients. Serum levels of myeloperoxidase (MPO)-ANCA, proteinase 3 (PR3)-ANCA, antinuclear antibody (ANA), anti-dsDNA antibody and extractable nuclear antigen (ENA) antibodies were measured by enzyme immune assay methods. Serum Complement C3 and C4 estimation was done by nephelometer. Unpaired t test was used to find the significance difference in mean value between ANCA positive and ANCA negative group. Chi-square test was used to compare categorical data of two groups.
Nineteen cases (20.65%) showed ANCA positivity. Ten cases were positive for PR3-ANCA and seven cases were positive for MPO-ANCA. Two cases were detected with dual MPO and PR3-ANCA. Nephritis was significantly more common in ANCA positive SLE patients. Rest all of clinical manifestations, anti-dsDNA antibody positivity, ENAs antibodies positivity and reduction in complement level did not show any significant correlation with presence of ANCA antibody.
In contrast to results of earlier studies, PR3-ANCA was more prevalent in our study population. Renal system involvement was significantly high in ANCA positive SLE patients as compared to ANCA negative patients.
Anti-neutrophil cytoplasmic antibody, Systemic lupus erythematosus, Prevalence
