Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2024
  • Volume: 17
  • Issue: 11

Green Solvent-Based UV Spectrophotometric Technique for Quantifying Molnupiravir in Bulk and Pharmaceutical Formulation

  • Author:
  • Gandi Anusha*, Shaik Nargiz, Allu Sireesha, Kona Poojitha, K. Varaprasada Rao, Y. Srinivasa Rao
  • Total Page Count: 5
  • Page Number: 5210 to 5214

Department of Pharmaceutical Analysis, Vignan Institute of Pharmaceutical Technology, Besides VSEZ, Kapujaggraju Peta, Duvvada, Visakhapatnam, Andhra Pradesh, 530049, India

*Corresponding Author E-mail: gandianusha11@gmail.com

Online Published on 06 May, 2025.

Abstract

A type of antiviral medicine called molnupiravir is used to treat viral infections. Using green solvent as methanol, a precise and affordable UV spectrophotometric technique has been created. It was demonstrated how to determine the Molnupiravir concentration in pharmaceutical dose formulations and bulk samples at a preset λmax of 236nm. Beer limitations were found to have a regression equation of (y=0.0457x-0.0031) and an excellent correlation coefficient (R2=0.999). The quantity of molnupiravir in marketed brands from local markets was determined using this method successfully, and the results were in excellent agreement with the claim on the label. According to the standards of the International Conference on Harmonisation (ICH), the method’s linearity, accuracy, precision, robustness, and ruggedness were all validated. The obtained outcomes demonstrated the method’s suitability for regular analysis of Molnupiravir in bulk as well as formulation.

Keywords

Molnupiravir, UV Spectrophotometric method, Accuracy, Linearity, Precision