Role Chitosan Film as a Catalyst for Rapid Gingival Healing: An Innovation in Periodontal Therapy

Healing of gingival wounds after periodontal surgery is a crucial aspect that influences the success of the procedure and patient comfort. Chitosan films, with their biocompatibility and biodegradability properties, have been explored as a drug delivery medium to accelerate tissue regeneration. This study aims to evaluate the effectiveness of chitosan film as a stimulant for gingival wound healing by increasing local drug delivery. Blood smear preparations assessed the immune cells, and Hematoxylin and Eosin staining evaluated the number of fibroblast cells, osteoblast cells, and osteoclasts. Meanwhile, the Il-1β titers were assessed using the ELISA assay. Film chitosan 30% has a good effect on maintaining immune cell responses, increasing the number of fibroblast cells, preventing gingival epithelial cell toxicity, increasing osteoblast cell function, and reducing alveolar bone osteoclasts. In addition, Its film 30% can reduce the response of IL-1β and post-gingival trauma. This study proves that chitosan film as a drug delivery agent can catalyze periodontal therapy, accelerating gingival healing. Thus, chitosan films offer a promising, innovative therapeutic strategy for application in periodontal surgery.