Tailoring Vilazodone Hydrochloride Delivery Systems with Natural Superdisintegrants for Enhanced Bioavailability

The work presented below aimed to successful development of optimized fast dissolving tablet of vilazodone hydrochloride with natural superdisintegrants prepared by Lepidum sativum Seed using “Quality by Design”. Central composite design was used to optimize the tablet formulation which was compressed by direct compression followed by sublimation technique with additive effect of natural super disintegrant The impact of independent variables i.e. natural super-disintegrant and sublimating agent at different concentration was determined on dependent variables like wetting time, disintegration time and drug release. The optimized batches were developed after validation using overlay plot technique of design expert, passes all the physical evaluation of tablets, it passes the compatibility studies as shown by FTIR, XRD and DSC TGA. Tablet also showed minimum wetting time, disintegration time and maximum the drug release in 5 m.. The developed optimized formulation employing CCD shows no significant changes during one month stability studies. This present work results in a completion with the development of compressed tablets for vilazodone hydrochloride with high porosity that dissolve rapidly in mouth to improve patient compliance and could be industrially feasible.