1Dept of Pharmacology, S.N.M.C and HSK Hospital and Research Center, Bagalkot, Karnataka
2Department of Pharmaceutical Chemistry, Nehru College of Pharmacy Pampady Thriuvilamala, Thrissur, 680588
3Dept of Pharmacology, Shri B. M. Patil Medical College, BLDE (Deemed To Be) University, Vijayapura, Karnataka
4Department of Pharmaceutics, HSK College of Pharmacy, Bagalkot - 587101, Karnataka
The aim of the study was to investigate the hypoglycemic effects of a newly synthesized thiophen-flavonoid(NF) a gamma-benzopyran in both normal and diabetic Wister albino rats fed a high-fat diet. Synthesized the test drug Novel flavonoid (NF) by condensation fallowed by cyclization reaction (of 2 hydroxy acetophenone and thiophen carbaxaldehyde in alkaline medium) was used in this study. The OECD 425 standards were adhered to and Swiss albino mice were used in the acute toxicity testing of the drugs used in the NF test. The potential hypoglycemic effect of NF on normoglycaemic, glucose loaded, and Streptozotocin-induced hyperglycaemic rats fed on HFD, at 50, 100, and 200mg/kg p.o. body weight were evaluated. For comparison, metformin (100mg/kg) was used as standard. Promising results were obtained by the synthetic flavonoid (NF) treated animals at 100 to 200mg/kg p.o dose, and are comparable to the metformin treated groups. The study directs the scientific base for flavonoid test drugs like NF can be used in oxidative metabolic diseases such as diabetes mellitus.
Benzopyrone, High fat diet(HFD), OGTT, Hyperglycemias, Streptozotocin
