Research Journal of Pharmacy and Technology

The applicability of medicinally imperative plants for well-being of human hold historical background. Products of natural origin are the pivotal source of medicament. Amid all, plant-rooted medicines are the exemplary natural source. The failure of allopathic medicines in terms of their aftereffect have tuned keen interest and practice of medicinal plants and their derivative products. The pharmacologically functional phytophenolics were amendable for the therapeutic attributes of medicinal plants. Acacia nilotica or A. nilotica (Babul/Kikar) an ayurvedic tree was used in this study. Applying soxhlation technique the aqueous bark extract from A.nilotica was pertained. GC-MS chromatogram elucidated 11 bioactive entities, connected with pharmacological traits that included 1,2,3-benzenetriol (Pyrogallol), estra-1,3,5(10)-trien-17β-ol, ethanamine, nonadecane, n-octadecane and pentanoic acid. Furthermore, n-hexadecanoic acid, octanoic acid, 1,2-benzenedicarboxylic acid, benzeneacetic acid and eicosane were recognized in the extract. Pseudomonas aeruginosa (14.6 ± 0.21 mm) displayed greater antibacterial activity, followed by Bacillus cereus (14.4 ± 0.38 mm), Staphylococcus aureus (13.6 ± 0.33 mm), Klebsiella pneumoniae (12.9 ± 0.30 mm), Bacillus subtilis (12.6 ± 0.24 mm) and the least inhibitory zone was given by Escherichia coli (10.2 ± 0.52 mm) at 40 μg/mL. All the outcomes validated the antibacterial attributes of A.nilotica bark pertained aqueous extract.