Formulation and evaluation of antidiabetic mucoadhesive microspheres

The present investigation was aimed to prepare alginate-acacia microspheres by ionic cross-linking method or Ionotropic gelation method. Systematic preformulation study performed as per the standard procedure as described for the identification and authentication of drug sample. Calibration curve was prepared as spectrum of this solution was recorded in 200-400 nm range using U.V. spectrophotometer. FT-IR spectrum of standard drug was done by FT-IR from 400-4000cm^-1 by using potassium bromide. Total 8 formulations (F1-F8) were prepared. The microsphere of Vildagliptin was preparedusing ionotropic gelation system also exhibited the smallest particle size of 176.65 micrometres. Formulation F4 exhibited the highest percentage entrapment efficiency of 78.85% with the highest percentage of mucoadhesion (70.23%). Formulation F4 has a zeta potential of -36.45 mV. A zeta potential with a magnitude above 30 mV (either positive or negative) typically indicates good stability in colloidal systems. The optimized formulation of the Vildagliptin loaded acacia-sodium alginate microspheres was tested after 3 months of storage at room temperature.