1Professor, Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai77, Tamil Nadu, India
2Assistant Professor, Department of Physiology, Sri Lalithambigai Medical College and Hospitals, Dr. M.G.R. Educational and Research Institute, Service Rd, Maduravoyal, Adayalampattu, Tamil Nadu, India
*Corresponding Author E-mail: drpreeth.homeo@gmail.com
Online published on 9 May, 2025.
Herbal medications are used to treat diseases and conditions with fewer adverse effects, ease of availability and low cost. So many bioactive compounds were identified from the plant, Andrographis paniculata . The objective of this study was to determine the molecular interactions of selected compounds with diabetes mellitus (DM) target protein Glucokinase. In this work, the screening of the best molecules as bioactive compounds is accomplished by a molecular docking study with chosen DM target protein. In this study, five possible bioactive compounds such as Andrographolide, 3,14,19-triacetylandrographolide, 14-deoxyandrographolide, Andrograpanin and Neoandrographolide have been successfully identified by binding energy as the most effective ligands for the management of diabetes mellitus.
Diabetics, Glucokinase, Andrographis paniculata, Molecular Docking
