New spectrophotometric methods for the determination of loratadine

Loratadine is a second-generation antihistamine that is used to treat allergic rhinitis and hives. New spectrophotometric techniques have been proposed for the estimation of Loratadine in pharmaceutical dosage forms. A double-beam SHIMADZU Model UV-1800UV-VIS spectrophotometer was used for the present study. Loratadine has shown linearity over the concentration range 0.5-50 μg/mL in borate buffer (pH 9.0), phosphate buffer (pH 5.8), phosphate buffer (pH 7.8), and distilled water, and the methods were validated as per ICH guidelines. The proposed methods are simple, and economical and can be successfully applied for the assay of Loratadine in pharmaceutical dosage forms.