1Department of Pharmacy, Comilla University, Cumilla, Bangladesh
10Professor, Dept of Biochemistry, Symbiosis Medical College for Women, Symbiosis International (Deemed University), Pune, India
11Aristotle University of Thessaloniki, Thesaaloniki, Macedonia, Greece
12Assistant Professor, Faculty of Medical and Health Sciences, Liwa College, Al Ain, Abu Dhabi, United Arab Emirates
13Dentistry Department, Al-Turath University, Baghdad, Iraq
14Department of Research and Development, Shing Huei Group, Taipei, Taiwan
15Department of Pharmacy, University of Asia Pacific, Dhanmondi, Dhaka-1205
2Department of Medical Laboratory Science, Komar University of Science and Technology, Sulaimaniyah, Kurdistan Region, Iraq
3Department of Life Sciences, Kristu Jayanti College (Autonomous), Bengaluru, Karnataka, India
4Óbuda University, Keleti Károly Faculty of Business and Management, Óbuda University, Tavaszmezo u. 15-17, H-1084, Budapest, Hungary
5Department of Pharmacy, East West University, AftabnagarDhaka-1212, Bangladesh
6College of Medicine, Al-Ayen Iraqi University, Thi-Qar, Iraq
7Research Secretary, Bangladesh Pharmacists’ Forum (Comilla University), Bangladesh
8Department of Medical Physics, College of Applied Medical Sciences, University of Kerbala, 56001, Karbala, Iraq
9Professor & Head Dept of Biochemistry, Symbiosis Medical College for Women, Symbiosis International (Deemed University), Pune, India
*Corresponding Author E-mail: pharmacist.rezwan@gmail.com
Online published on 9 May, 2025.
Drug development is both a task and a promise for fighting illnesses and improving health. Innovative treatments for cancer, infectious diseases, chronic illnesses, and uncommon genetic abnormalities have long been difficult and resource-intensive to develop. In the 21st century, bioinformatics has become a pioneering and essential technique for drug development. Bioinformatics uses computational algorithms, statistical analysis, and data-driven insights to understand life's core biological processes. Bioinformatics helps drug discovery researchers understand illness biological mechanisms, identify therapeutic targets, screen candidate molecules, and improve drug development pipelines. Drug development has been defined by fortuitous discoveries and tedious laboratory work, requiring years or decades to get a possible therapeutic agent to the patient bedside. Bioinformatics has transformed drug development in biomedicine today. This comprehensive study examines how bioinformatics has changed medication development. We want to study and analyse bioinformatics' many uses. We discover the complex network of genomes, proteomics, structural biology, and computational modelling that underscores bioinformatics' vital significance as we investigate this dynamic subject. This review illuminates the difficult balance between biological knowledge and computational capabilities to produce innovative treatments. The systematic review uses a thorough literature search, study selection criteria, and data extraction. Genomic target identification, virtual screening, pharmacophore modelling, pathway analysis, and toxicity prediction are among the bioinformatics applications in drug development we find and classify. These examples demonstrate bioinformatics' ability to accelerate medication development. The systematic review covers bioinformatics' drug discovery applications and shows how this diverse discipline is changing pharmaceutical research. It shows how to improve medication development, reduce side effects, and achieve precision medicine. The combination of bioinformatics and drug development offers optimism for easing human suffering, extending lifespans, and fighting a broad range of illnesses.
Drug development, Bioinformatics, Drug Discovery, Virtual Screening, Pharmacophore Modelling, Etc
