Prostaglandin in enhancing orthodontic tooth movement: A scoping review

The review aims to find and summarise scientific evidence suggesting that the use of prostaglandins improves orthodontic tooth movement. Four electronic databases were chosen: PubMed (US National Library of Medicine, USA), Scopus, EBSCO, and ProQuest. The databases were chosen to be comprehensive and to span a wide range of fields. There is no year limit. The languages of English and Bahasa Indonesia were considered, and the subject or type was entered into the database search. Two independent reviewers extracted the data and assessed the study's quality. The 661 initial data were identified from 4 electronic databases, of which 5 made up the final data. Healthy human and animal patients underwent active orthodontic treatment with fixed orthodontic equipment. Local or systemic biologic drugs (prostaglandins) are employed to accelerate orthodontic tooth movement.\. The results revealed that prostaglandins can enhance the rate of orthodontic tooth movement. There are two methods to enhance orthodontic tooth movement using prostaglandin. First, using PGE₂ injection with the dosage of 0.1g - 1.0g showed effectiveness. Second, using peroral with an optimum dose of 10-25g/kg/day.