Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2024
  • Volume: 17
  • Issue: 3

Mesenchymal stem cell secretome as novel regenerative approach in oral ulcerative lesions management: A review

  • Author:
  • Satutya Wicaksono1, Jola Rahmahani2, Diah Savitri Ernawati3, Fedik Abdul Rantam3, Theresia Indah Budhy4,5, Alexander Patera Nugraha6,7,*, Reyhan Mahendra Nur6, Nuraini Indrastie, Nastiti Faradilla Ramadhani7,8, Tengku Natasha Eleenabinti Tengku Ahmad Noor9,10
  • Total Page Count: 6
  • Page Number: 1408 to 1413

1Graduate Student of Immunology, Postgraduate School, Universitas Airlangga, Surabaya, Indonesia

10Malaysian Armed Forces Dental Officer, 609Armed Forces Dental Clinic, Kem Semenggo, Kuching, Sarawak, Malaysia

2Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia

3Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

4Immunology Study Program, Postgraduate School, Universitas Airlangga, Surabaya, Indonesia

5Department of Oral and Maxillofacial Pathology, Universitas Airlangga, Surabaya, Indonesia

6Department of Orthodontics, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

7Graduate Student of Dental Health Science, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

8Department of Dentomaxillofacial Radiology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

9Membership of Faculty of Dental Surgery, Royal Collage of Surgeon, Edinburgh University, United Kingdom

*Corresponding Author E-mail: alexander.patera.nugraha@fkg.unair.ac.id

Online published on 3 June, 2024.

Abstract

Paracrine effects exerted by trophic factors secreted by the mesenchymal stem cell (MSCs) are now considered the primary mechanism of regenerative abilities. These trophic factors, comprised of various growth factors, cytokines, microvesicles, and exosomes, are collectively called MSC secretome (MSC-S). MCS-S is thought to be a promising means of regenerative therapy. Architectural and functional oral epithelial loss in oral ulcerative lesions (OUL) may become the proper target for MSC-S regenerative therapy. Several pre-clinical studies have been conducted to assess the potential of MSC-S to facilitate OUL healing.

Thus, this article attempts to review current relevant studies regarding the applicability of MSC-S for OUL management.

This review was based on a literature search on several sites (PubMed, Scopus, ScienceDirect) with specific keywords "MSC secretome", “regenerative therapy”, "oral ulcer", and "regenerative therapy", "wound healing".

A total of 37 articles were included in this review. Conclusion: Based on the results, we concluded that MSC-S could improve oral mucosa regeneration and repair. Thus MSC-S would be a promising therapy for OUL therapy.

Keywords

Dentistry, Medicine, Conditioned medium, Mesenchymal stem cells, Regenerative medicine