1Department of Cellular and Molecular Biology, Faculty of the Sciences of Nature and Life, El-Oued University, El-Oued, 39000, El Oued, Algeria
2Laboratory of Biodiversity and Application of Biotechnology in the Agricultural field, Faculty of the Sciences of Nature and Life, University of El Oued, El-Oued, 39000, Algeria
*Corresponding Author E-mail: dersamebio@gmail.com
Online published on 10 June, 2024.
This investigation was aimed to study the effect of leaves aqueous extract of Ocimum basilicum L. (ObE) for prevention of cardiotoxicity and heart failure induced by doxorubicin in rats. For in-vivo rats study, 15 female albino Wistar rats were divided into 3 groups (n = 5); control group, doxorubicin treated rats group (DOX) and rats co-treated with doxorubicin and aqueous extract of O. basilicum group (DOX + O. basilicum. Various hematological, enzymatic, and oxidative stress markers were estimated. Histopathology of heart tissues was observed. Results of in-vivo rats study show that doxorubicin treated rats induced elevation in doxorubicin level in heart tissue, alteration in hematological parameters and enzymatic activity compared to control group. In addition, doxorubicin treated rats induced oxidative stress and histological alteration in heart cells compared to control rats. Co-treatment of doxorubicin with leaves aqueous extract of O. basilicum were partially reversed all of previous parameters. This study indicated that the anti-inflammatory and antioxidant property of leaves aqueous extract of O. basilicum allowed using them to protect organs from the side effects of doxorubicin or from the destructive effects of various diseases.
Ocimum basilicum L., Cardiotoxicity, Doxorubicin, Oxidative stress, Rat
