1Department of Pharmaceutics, Bengal School of Technology (A College of Pharmacy), Delhi Rd, Chinsurah R S, Sugandha, West Bengal, 712102, India
2Department of Pharmaceutics, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Banitabla, Uluberia, Howrah, West Bengal-711316
*Corresponding Author E-mail: soumyadip.phd@gmail.com
Online published on 13 June, 2024.
To deliver Nisoldipine (Nsp) transdermally, new particulate carriers have been prepared, such as stable solid lipid nanoparticles (SLNs) and nanostructured lipid carriers as gel form, using a two-factor, three-level central composite design (CCD).
For this experiment, The Nsp-SLNs gel was prepared using carbopol 940.We fabricated SLNs with stearic acid and tween 80 using a modified solvent diffusion method.
Particle size, zeta potential, polydispersity index, and in-vitro dissolution studies of the prepared nanoparticles were evaluated for their optimal use. Rat abdominal skin was also investigated for percutaneous permeation of Nsp-SLNs. Analyzing the particle size by photon correlation spectroscopy (PCS)using Malvern Zetasizer, which shows that the Nsp-SLNs are in the range of 75.49±0.63nm to 106.41±0.63nm. The entrapment efficiency (EE%) among all 9 Nsp-SLN formulations fell around 84.14±0.5% and 86.14±0.25%.
An in-vitro drug release test was conducted over a period of 12 hours. Formulation F4 showed the optimum result based on the response surface methodology. Nsp-SLNs and Nsp-SLNsgels were successfully formulated using stearic acid and tween 80 was subjected to transdermal use. Nsp-SLNs feature a steady zeta potential window with a monodispersing range, a uniform particle size distribution within the nanoparticle range, and good encapsulation effectiveness. Higuchi and zero-order kinetics were used to predict the in-vitro release of Nsp-SLNs and gels supplemented with stearic acid and tween 80.
Solid lipid nanoparticles, Nisoldipine, Transdermalgel, Optimization, Nano-emulsion, Entrapmentefficiency, Experimental design
