Department of Pharmaceutics, Dadasaheb Balpande College of Pharmacy, Besa, Nagpur, Maharashtra, India
The oral route is widely used route of administration as it is safe and convenient. Nanostructured lipid carriers (NLCs) are made of liquid, solid, and surfactant lipids. More drug loading is possible because of the imperfect structure of the lipid matrix in nanostructured lipid carriers.NLCs are biocompatible, biodegradable and show good encapsulation efficiency.They are considered promising nanocarriers for oral delivery. NLCs have been demonstrated to increase the oral bioavailability of hydrophobic pharmaceuticals. They also circumvent hepatic metabolism and impede drug efflux via the P-glycoprotein. This review focuses on the importance of NLCs in drug administration via the oral route, as well as the many hurdles that must be overcome.
Lipids, Absorption, Bioavailability, Oral
