Research Journal of Pharmacy and Technology

SCOPUS
  • Year: 2024
  • Volume: 17
  • Issue: 6

BCS Class II and IV drug´s solubilisation using cycodextrin-PVP-PEG6000 complexes through a factorial study design

  • Author:
  • Soumaya El Baraka1,*, Siham Yanisse2, Ali Cherif Chefchaouni1, Aicha Fahry1, Abdelkader Laatiris1, Naoual Cherkaoui1, Yasser El Alaoui1, Younes Rahali1
  • Total Page Count: 5
  • Page Number: 2639 to 2643

1Team of Formulation and Quality Control of Health Products, Laboratory of Pharmaceutics, Faculty of Medicine and Pharmacy, Mohammed V University of Rabat, Rabat, Morocco

2Galenic Laboratory of Faculty of Medicine and Pharmacy of Marrakesh, Cadi Ayyad University of Marrakesh

Abstract

Class II and IV drug on the Biopharmaceutical Classification System are those with the commonest solubility issues. The objective of this work is to study the effect of the use of cyclodextrin combined with each PVP, and PEG 6000 individually, then combined, and the enhancement of solubility and dissolution rate on three BCS class II celecoxib and Valsartan, and Class IV Furosemide.

A serie of 23factorial experiments were conducted. Drug´s solubilities were assessed in eight selected fluids containing Beta Cyclodextrin, Polyvinylpyrrolidone and Poly Ethylene Glycol 6000 individually and in binary and ternary combinations. Solid inclusion complexes of each drug beta Cyclodextrin, Polyvinylpyrrolidone and Poly Ethylene Glycol 6000 were prepared by kneading method, to evaluation the impact of each excipient on dissolution rates per 23factorial design.

Solubility levels of the three studied drugs was highly enhanced by the studied excipients. The highest solubility improvement was recorded for the combination of βCD with PEG 6000 (4,95ratio) IN THE CASE OF Celecoxib, and forβ-CD in combination with PEG 6000 and PVP (25,52 ratio) in the case of FSD, then in the combination of βCD with PEG 6000 (21, 41ratio) in the case of Valsartan. The highest enhancement of celecoxib dissolution rates was recorded for CCX-βCD (1:2) - PEG 6000 (2%) combination (10,03 ratio), for FSD- βCD (1:2)-PEG 6000 (2%)-PVP (2%) combination (22,61 ratio) in the case of furosemide and for VST-PVP (2%) combination (3,54ratio) in the case of Valsartan.

PEG 6000 is a suitable solubilizer alone and in combination with βCD and PVP to enhance the solubility and dissolution rate of the selected three BCS Class II and IV drugs.

Keywords

Solubility, Dissolution, Cyclodextrin, PVP, PEG 6000