Naringi crenulata leaf extract alleviates beta amyloid protein induced alzheimers disease in mice

Oxidative stress is involved in Alzheimers disease(AD)-type neurodegeneration with cognitive impairment, as well as age-related cognitive loss. The purpose of this study was to investigate the effects of Naringi c renulata leaf extract (NCLE) on cognitive dysfunction, oxidative stress in the hippocampus in a mouse model of beta-amyloid-induced AD. The animals were given NCLE at two different doses (50mg/kg and 100mg/kg, orally) for 21 days. On the day 15^th receiving intracerebroventricular-amyloid beta peptide_25-35 injection (3mg/kg; single dose). Y maze and morris water maze paradigms were used to examine behavioural changes on the day 22. On the 22^nd day, mice were sacrificed to measure malonaldehyde (MDA), myeloperoxidase (MPO), nitric oxide (NO), reduced glutathione (GSH), glutathione-S-transferase (GST), superoxide dismutase (SOD), catalase (CAT) in mouse brain tissues. The enhancement of habituation memory and the step-down inhibitory memory in the experimental animals. Pro-inflammatory cytokines levels were decreased and anti-inflammatory cytokines were enhanced. The study implies that NCLE can protect against cognitive impairments and oxidative stress caused by amyloid beta, and that it could be employed as a adjunct therapy in the treatment of neurodegenerative illnesses such as Alzheimers.