Formulation and evaluation of curcumin, honey and silver nanoparticles for antibacterial and burn wound healing

Restoring the skin and tissue after an injury is a dynamic and complex process called wound healing. Several factors could influence how well a wound heals, including, oxygenation, sex, age, nutrition, hormones, drugs, diabetes, eating habits, smoking, and alcoholism. Nanotechnology is on the verge of offering a range of innovative technologies and methods that would revolutionize the medical and pharmaceutical sectors. The objective of the current study was to evaluate the antibacterial and wound healing of curcumin, honey, hydrogel embedded silver nanoparticles in an experimental animal rat. Formulations F1, F2, F3, F4, F5 and F6 of Silver nanoparticles embedded hydrogels were prepared and were subjected for characterization using UV Spectroscopy, Scanning electron microscopy (SEM) and X-ray diffraction analysis (XRD). SEM clearly showed the presence of synthesized nanoparticles. F2 formulation showed the maximum zone of inhibition which is a clear indication of antibacterial activity. Formulation F2 was found to be very good as compared to all other formulation. All the evaluation parameters showed good activity but formulation F2 was found to be the optimum and a very good antimicrobial agent. In the rat model silver nanoparticles “hydrogel” was more successful in burn wound healing than the commercially available brand of Silver sulfadiazine gel which was taken as standard.