1University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India
2School of Pharmaceutical Sciences, RIMT University, Mandi Gobindgarh, Punjab, India
3Faculty of Pharmaceutical Sciences, Lal Bahadur Shastri College of Pharmacy, Tilak Nagar, Jaipur, Rajasthan
4University Institute of Pharmaceutical Sciences, Chandigarh University, Mohali, Punjab
5Department of Biosciences, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences, Chennai - 602105, Tamil Nadu, India
6Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, China
7King Fahd Medical Research Center, King Abdulaziz University, Saudi Arabia
8Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Bangladesh
9Enzymoics, 7 Peterlee Place, Hebersham, NSW2770, Novel Global Community Educational Foundation, Australia
Degenerative diseases of nerves are associated with the progressive loss of a specific function of neurons resulting in cell death or some abnormal functions of organs. Neurodegeneration is associated with dysfunctioning of well-being and involves muscular symptoms like tremor, loss of memory, diminished intellect and speech problems, weak or paralyzed muscles, numbness, and partial loss of senses. Heterocyclic compounds have a wide range of structural diversity and have proven to be widely and economically useful as therapeutic agents. Extensive research on the therapeutic potentials of heterocyclic compounds has confirmed their enormous importance in the pathophysiology of neurodegenerative diseases. Various researchers have evaluated the neuroprotective activity of various heterocyclic nuclei. Despite the availability of many heterocyclic drugs against these disorders, a satisfactory treatment is still not available to rely upon. Herbal treatments are gaining the interest of researchers due to their wide availability with the least side effects. The purpose of this review article is to go over the research that has been done on the neuroprotective potentials of heterocyclic scaffolds in comparison with the upcoming herbal treatments to treat degeneration of nerves.
Alzheimer’s disease, Parkinson’s disease, Heterocycles compounds, Neuroprotective activity, Herbals
