Stomach specific novel floating in-situ gel for sustained drug delivery: Overview

The floating drug delivery system (FDDS) is a promising gastro retentive drug system that offers advantages such as improved stomach retention and enhanced effectiveness of medicinal treatment. Over time, oral drug delivery systems have evolved from immediate release to delayed release, site-specific delivery, and sustained release, with the primary goal of enhancing bioavailability and predictability of drug action. One particular type of gastric retention system, the floating in-situ gelling system, has gained attention for its innovative drug delivery approach, leveraging the unique physiology of the stomach. This review study explores the preparation, materials, mechanism, and action of the floating in-situ gelling system within the stomach, highlighting important findings. Furthermore, it examines the efficacy of the system's mechanism. Currently, oral administration accounts for approximately half of the medication delivery systems available in the market, mainly due to its ease of use and high patient compliance. Among the various methods of oral drug administration, floating drug delivery systems have emerged as a focus of ongoing research and development efforts.