Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2024
  • Volume: 17
  • Issue: 7

Analysis of CT value, levels of C-reactive protein, and procalcitonin as inflammatory markers in COVID-19 patients with and without comorbidities at the Rumah Sakit KhususInfeksi (RSKI) Universitas Airlangga Surabaya

  • Author:
  • Retno Budiarti1,*, Ediono2, Muhammad Miftahussurur3,4, Muhammad Abdulloh Machin5, Wiwin Is Effendi6, Mochammad Wijdan Rosyich7
  • Total Page Count: 5
  • Page Number: 3389 to 3393

1Microbiology Departement, Hang Tuah University, Surabaya, Indonesia

2Pulmonology DepartmentNaval Hospital, RSAL Dr Ramelan, Surabaya, Indonesia

3Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine/Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, Indonesia

4Helicobacter Pyloriand Microbiota Study Group, Institute of Tropical Disease, Airlangga University, Surabaya, Indonesia

5Rumah Sakit Khusus Infeksi, Airlangga University, Surabaya, Indonesia

6Pulmonology Department Faculty of Medicine, Airlangga University, Surabaya, Indonesia

7Neurology Department Faculty of Medicine/Dr. Soetomo Teaching Hospital, Airlangga University, Surabaya, Indonesia

*Corresponding Author E-mail: dr.retnobudiarti74@gmail.com

Online published on 29 April, 2025.

Abstract

Detection of SARS CoV19 with RT-PCR on nasopharyngeal swab specimens became the gold standard and the Ct value as the result was described the amount of viral RNA. It is used to assess the severity and management of patients. C-reactive protein (CRP) and procalcitonin are markers of inflammation. We aimed to analyze the relationship between Ct values, CRP, and procalcitonin with the progression of COVID-19 infection in patients with comorbidities and without comorbidities.

We included 561 COVID-19 patients’ data obtained from medical records at RSKI UNAIR within a 5-monthperiod (June-November 2021). The statistical analysis of each parameter was observed between the two groups (with and without comorbidities).

There are significant differences in CT PCR, procalcitonin, and CRP values in patients with comorbid hypertension. There was no significant difference in CT PCR values, procalcitonin levels, and CRP in patients with comorbid asthma. There was no significant difference in CT PCR values in the group with comorbid DM, but the procalcitonin and CRP values obtained significant differences.

Patients with comorbid hypertension and diabetes mellitus can experience more severe COVID-19 infections.

Keywords

Viral load (RNA), Inflammatory marker, Comorbid