The Role of Oligomeric-Grape Seed Proanthocyanidine Extract (O-GSPE) on Cholestasis Liver Damage in Animal Model

The use of herbal plants as an alternative treatment for hepatobiliary disease is still being carried out.This study plans to examine the capability of oligomeric- grape seed proanthocyanidine extract (O-GSPE) in shielding the liver from injury brought about by cholestasis, which is prompted by bile duct ligation (BDL) as a creature model. Grown-up male rats were utilized and haphazardly separated into 3 treatment gatherings. C- was the negative control bunch, bile duct ligation (BDL) was the bunch that was treated with bile duct ligation (BDL) and the bile duct ligation (BDL)+oligomeric- grape seed proanthocyanidine extract (O-GSPE) bunch was given the bile duct ligation (BDL) treatment and given oligomeric- grape seed proanthocyanidine extract (O-GSPE) orally at measurements of 400mg/kg BW/day, beginning on the moment day after bile duct ligation (BDL) and given for 21 days. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT) were assessed employing a spectrophotometer; interleukin 6 (IL-6) and transforming growth factor beta 1(TGF-β1) were assessed utilizing histopathological examination with Hematoxylin and Eosin (HE) staining and immunohistochemistry. In this study, the results showed that liver morpho-function was significantly improved by the administration of oligomeric- grape seed proanthocyanidine extract (O-GSPE).