1Department of Pharmacology, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote – 587101
2Department of Pharmaceutical Chemistry, BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote – 587101
*Corresponding Author E-mail: naveenmaled1007@gmail.com
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Online Published on 30 April, 2025.
To examine the effect of Cansjera rheedii in gentamicin induced kidney damage in rats.
In this current study, rats in group 1 were used as the normal group and were given physiological saline. Rats of group 2 were injected with gentamicin [100mg/kg] via intraperitoneal injection. Group 3 was given gentamicin (100mg/kg, IP) together with oral selenium [2mg/kg]. Hydroalcoholic extract (HECR) of Cansjera rheedii leaves was administered orally to groups 4 and 5 in low dose of 200mg/kg and high dose of 400 mg/kg, respectively. Above treatments were given to rats over eight days. Blood serum and urine were collected on the 8th day to evaluate blood and urine biochemical parameters. Antioxidant parameters were evaluated using renal homogenates. Kidney sections were used for histopathological examination.
The renoprotective effect of HECR plant extract was evident at both low and high dose [200mg/kg and 400mg/kg]. This action maintains structural and functional integrity by preventing damage caused by gentamicin. This protection is attributed to the antioxidant properties of the extract.
Cansjera rheedii, Kidney damage, Oxidative stress, Apoptosis, Nephroprotective, Gentamicin
