New preeclampsia calculated factor (PF) detecting severity in healthy, mild and severe cases

Preeclampsia (PE) is a disorder of pregnancy characterized by the onset of high blood pressure and often a significant amount of protein in the urine. There is no individual marker satisfactory for the prediction of PE occurrence and many markers have been studied to discover the gold standard test that predicts the boundaries of PE severity. In this comparative case- control study, 118 pregnant women were recruited (44 healthy, 44 with mild PE and 30 with severe PE). The total serum bilirubin, glucose, BUN, total serum protein, albumin, alanine transaminase (ALT), aspartate transaminases (AST), gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) were measured. There were significant differences in all of the biochemical parameters in the severe PE groups when compared with the healthy control groups; a P value of < 0.001. However, significant associations were not observed for age, gravidity, and gestational age. Three parameters: GGT, total serum bilirubin, and albumin, achieved the highest percent of alteration in relation to healthy control levels; the values 320.66%, 50%, and – 26.21% respectively. These parameters are used to calculate the preeclampsia factor (PF), which was then engaged in detecting the boundary lines of PE groups and the interference areas or overlapping between peaks. The gathering of many biochemical parameters in one equation is a good approach to produce a factor that represents a reliable biochemical tool used successfully to outline the boundaries of PE groups and display the areas of overlap between them. This preeclampsia factor is a promising biochemical tool in patient monitoring, treatment, follow-up, and facilitating pregnant health care.