Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2024
  • Volume: 17
  • Issue: 9

The relationship between natural resistance – associated macrophage protein 1 (NRAMP-1) levels and Hb and body mass index (BMI) in tuberculosis lymphadenitis patients

  • Author:
  • Fathul Djannah1, Anny Setijo Rahaju2, Muhammad Nasrum Massi3,*, Mochammad Hatta3, Agussalim Bukhari4, Irda Handayani5
  • Total Page Count: 5
  • Page Number: 4422 to 4426

1Dept. of Anatomical Pathology of Medical Faculty, Universitas Mataram, Mataram, West Nusa Tenggara, Indonesia

2Dept. of Anatomical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia

3Dept. of Microbiology of Medical Faculty, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia

4Dept. of Nutrition of Medical Faculty, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia

5Dept. of Clinical Pathology of Medical Faculty, Universitas Hasanuddin, Makassar, South Sulawesi, Indonesia

*Corresponding Author E-mail: nasrumm2000@yahoo.com

Online published on 30 April, 2025.

Abstract

Tuberculosis lymphadenitis (LnTB) is the most common extrapulmonary tuberculosis (EPTB). The NRAMP-1 gene is located in macrophages which functions to secrete iron needed by MTB to live. Enzyme-linked immunosorbent assay (Elisa) is a serological test commonly used in various immunology laboratories.

This study aimed to investigate the relationship of NRAMP-1 levels with Hb and BMI in tuberculosis lymphadenitis patients.

This study is a descriptive cross-sectional carried out from January to September 2021 on 50 LnTB patients. Blood was taken before treatment and then an ELISA examination was performed to determine NRAMP-1 levels, as well as an Hb examination. Nutritional status was determined by body mass index (BMI) assessment.

Of the 78 respondents, 34.6% are male and 65.4% are female. The mean age of the respondents in this study is 26.89. Histopathologically, it was found that 56.4% are well-organized granulomas and the respondent patients are mostly from Mataram with a percentage of 30.7%. The mean nodule complaint is 3.0064 cm. The mean NRAMP-1 level is 256.88, the mean Hb is 12.05, and the mean BMI is 20.31. After the spearman-rho test, it was found that the relationship between NRAMP-1 levels and Hb is p=0.018 and the relationship between NRAMP-1 levels and BMI is p=0.242.

There is a relationship between NRAMP-1 levels and Hb. However, there is no significant relationship between NRAMP-1 levels and BMI.

Keywords

Limfadenitis tuberculosis, Tuberculosisi, LnTB, Elisa NRAMP-1, Body Mass Index