Formulation and evaluation of gymnemic acid loaded PLGA nanoparticles

In the present study, Gymnemic acid nanoparticles was prepared by using PLGA (Polylactic-co-glycolicacid) polymer, surfactant sodium alginate and evaluate its ideal concentration of polymer based on its in vitro release profile for a period of 24hrs. The nanoparticles were prepared by solvent evaporation method by using various concentration of PLGA (Polylactic-co-glycolic acid) and the different formulations are (GLPNP1, GLPNP2, GLPNP3). The nanoparticles were evaluated by particle size, zeta potential, drug content, entrapment efficiency and the invitro drug release. There is no incompatibility between drug and other excipients used in the formulation, have been proved in the preformulation studies. Based on the entrapment efficiency and invitro drug release profile the formulation which contain 500mg of PLGA (Polylactic-co-glycolic acid) (GLPNP3) was selected as a best formulation for the control release of Gymnemic acid for a period of 24hrs.