Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2024
  • Volume: 17
  • Issue: 9

In-vitro evaluation of antioxidant and anti-diabetic activity of Canavalia gladiata (Jacq.) DC.

  • Author:
  • Mrinalini Pal1,2, Nem Kumar Nagpoore1,2, Sushil Agrahari2, Bhramanand Singh2, Vashist Narayan Pandey1,*
  • Total Page Count: 4
  • Page Number: 4515 to 4518

1Experimental Botany and Nutraceutical Laboratory, Deen Dayal Upadhyaya Gorakhpur University, Gorakhpur - 273009, Uttar Pradesh, India

2Pharmacogynosy, Phytochemistry and Product Development, CSIR NBRI, Lucknow - 226001, Uttar Pradesh, India

*Corresponding Author E-mail: vnpgu@yahoo.co.in

Online published on 30 April, 2025.

Abstract

The present study was to investigate antioxidant and anti diabetic activities of Canavalia gladiata. The plant extract from different parts of C. gladiata was investigated for its TPC and TFC content. the seed showed highest TPC content 77.015±0.21μg GAE/mg extract and leaf showed highest TFC content 150.350±0.22μg Rutin E/mg dry extract. Antioxidant activity was investigated by DPPH and ABTS methods based on IC50 value, the seed showed highest DPPH and ABTS value 275.125±0.58μg/ml and 7.848±0.17μg/ml respectively. The anti diabetic activity was investigated by α- amylase and α- glucosidase the result showed highest activity by stem i.e. 838.057±1.00μg/ml and 659.638±0.89μg/ml respectively. Result revealed the positive effect of plant extract for anti diabetic activity which could be potentially used for development of herbal medicine or food supplement i.e. nutraceutical in near future.

Keywords

Canavalia gladiata, Antioxidant, Diabetes mellitus, Anti diabetic, α- amylase, α- glucosidase