1Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, India
2Geeta Institute of Pharmacy, Geeta University, Naultha, Panipat, Haryana, 132145, India
3Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, Delhi, 110017, India
4MM College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, Haryana
*Corresponding Author E-mail: tanujhooda2010@gmail.com
Online published on 14 May, 2025.
To determine GABA1A receptor agonist activity of linalyl acetate by using combination of linalyl acetate with alprazolam. To determine 5HT1A receptor agonist activity of linalyl acetate by using combination of linalyl acetate with Buspirone. To determine anxiolytic potential of linalyl acetate in drug induced anxiety by using linalyl acetate in combination with caffeine. To determine the effect of linalyl acetate on locomotor activity in mice by using actophotometer.
Alone Linalyl acetate and combination of linalyl acetate with alprazolam, buspirone and caffine were evaluated for anxiolytic effect in mice by using elevated plus maze, light and dark apparatus. The locomotor activity of swiss albino mice was identified by using open field apparatus and actophotometer. After amputation and homegenization estimation of antioxidants levels and neurotransmitters level was done for determination of anxiolytic effect.
The anti-anxiety effect of linalyl acetate 400mg/kg can be comparatively equal or less than linalyl acetate in combination with alprazolam and linalyl acetate in combination with buspirone but, linalyl acetate 400mg/kg can be comparatively equal or better effective than linalyl acetate in combination with caffeine.
The current study demonstrates statistically significant dose-dependent antianxiety activity of linalyl acetate and combination of linalyl acetate with alprazolam, buspirone and caffine.
Antianxiety effect, Biochemical parameter, Elevated plus maze, Light and Dark apparatus, Open Field Apparatus, Actophotometer
