Pharmacokinetic evaluation of telmisartan chronotherapeutic press coated tablets

Ocimum gratissimum mucilage isolated from Ocimum gratissimum seeds at raised temperatures was a white crystalline powder. The modified mucilage derived from Ocimum gratissimum exhibits remarkable flow properties and exhibits insolubility in water and aqueous solutions across a range of alkaline and acidic buffers. It likewise showed excellent water edema (90%) as well. When cooked to 100°C for 30 minutes in water, it does not gel. It was tested as a disintegrant in tablet forms and is thought to be a promising disintegrant. Telmisartan tablets were tested after being manufactured using a direct compression method with 0-10% Ocimum Gratissimum mucilage as a novel super disintegrant. The level of independent factors (sodium starch glycolate, croscarmellose sodium, and Ocimum Gratissimum mucilage) on dependent variables (disintegration time, water absorption, wetting time, and percent release in 5 minutes) in the formulations were optimised using a 2x3 factorial design. After that, the enhanced recipe was press-coated in various ratios with naturally occurring time-released polymers such Gardenia Gummifera and Anogeissus latifolia gum. Based on post-compression properties, the best formulation was selected, and dissolution data underwent three months of accelerated stability testing of the ten coating formulations. Impressive outcomes were observed with F2CC6, with a maximum cumulative medication release of 99.54% in a 12hour period. Due to its release pattern and capacity to administer the medication at the proper time, location, and dosage, the suggested delivery technique exhibits significant promise for hypertensive patients.