Emerging implementation of praziquantel drug loaded with self-micro emulsifying drug delivery system to enhance the antischistosomal efficacy

Schistosomiasis is a medical condition triggered by blood worms that infect several organs, including the colon, bladder, liver and urethra. There are 5 species capable of infecting humans. The three most frequent strains are S. haematobium, S. japonicum, and S. mansoni.

The preferred medication for treating human fluke infections like schistosomiasis is praziquantel (PZQ).

To choose the best component combination, the solubility of the PZQ was calculated in a variety of solvents. Smix ratios 1:1, 2:1, and 3:1 was chosen for 9 formulations containing oleic acid.

The improved formulation F5 has a 98.02% transmittance, a cloud point of 85.3°C and the globule size of formulation was found to be 282.7nm which enhance the penetration efficiency of drug.

Outcomes suggest that PZQ-loaded SMEDDS exhibited improved solubilization and potential to promote medication absorption.