Analysis of the potential preparation of Jamblang (Syzygium cumini (L) Skells) leaf extract gel for healing wounds in the mouth

Traumatic ulcers are reactive lesions of the oral mucosa with injured epithelial tissue. Neutrophils, macrophages, and lymphocytes are inflammatory cells that contribute in the healing of traumatic ulcers. Jamblang leaf extract gel 40% (Syzygium cumini (L.)) includes phytochemical components that aid in the healing of traumatic ulcers. The aim of this study was to determine the effectiveness of Syzygium cumini (L.) leaf extract gel 40% at reducing the number of inflammatory cells in the healing of traumatic oral mucosal ulcers. A total of 12 male Wistar white rats (Rattus norvegicus) were divided into 6 groups. Syzygium cumini (L.) leaf extract gel 40% was applied to the treatment group, triamcinolone acetonide 0.1% was applied to the positive control group, and gel base was applied to the negative control group. Traumatic ulcer manipulation at the apex of the rat tongue was performed using a hot burnisher for one second. Followed by applying a thin layer to the traumatic ulcer in twice a day for 3 and 7 days. The rats were euthanized, and the tongue apex was excised for preparing histological preparations and to count the quantity of inflammatory cells. The results revealed that the only significant difference was seen on 3^rd day in the number of macrophages in each group. It was discovered that Syzygium cumini (L.) leaf extract gel 40% reduced the quantity of macrophages on 3^rd day in male Wistar white rats with traumatic ulcers of the tongue apex.