Research Journal of Pharmacy and Technology

Aloin is an anthraquinone glycoside with high-volume applications in food and pharmaceutical products. In this work use of polyvinyl alcohol was first used, as per previous work mentioned inthe literature to dissolve the aloin molecule while entrapping it poly (D, L-lactide-co-glycolide) PLGA, the study investigates the aloin nanoparticles by using an important tool of drug design software stat expert 13 version. The nanoprecipitation process is used for Aloin nanoparticle formulation by involving PLGA polymer and optimizing the formulation by central composite (CC) design of response surface. The experiment was designed using four criteria, as described in the article, and two factors were investigated to improve the size of particles and (EE) entangled efficiency of drug aloin. The optimal formulation of the drug was characterized by various parameters involving Scanning, transmission Microscopy i.e. (SEM-TEM), and in vitro release parameters. With a zero-order release parameter, the formulation had an EE of drug 98.06% and a drug particle size of 98.5nm. The result of aloin nanoformulation with the help of statistical experimental design demonstrates that the optimized aloin formulation of nanoparticles improves the bioavailability and the process variables to achieve a favorable result.