Hepatoprotective and wound healing activities of the Halymenia ceylanica harvey ex kutzing in wistar albino mice

The natural products used for pharmacotherapeutic effects have impressed among the sapiens globally. Marine macro algal components have their proven potential with positive affects in therapeutics substituted for the synthetic derived drugs in the modern allopathic medication system. The liver is one of the vital organs in the body, serving as a hub for nutrition metabolism and excretion of waste products. Hepatotoxicity is a toxic illness that harms the liver caused by an overdose of drugs such as acetaminophen. Red algae have numerous biologically active phytochemical compounds with specific biological functions including various therapeutic actions like anticancer, antiulcer, antioxidant, antimicrobial, hepatoprotective and wound healing activities. The present study was designed to screen the hepatoprotective and wound healing activity of Halymenia ceylanica Harvey ex Kutzing. The dosage of 200 mg/kg and 400 mg/kg was prepared by the ethanolic extract of Halymenia ceylanica for hepatoprotective activity. Acetaminophen (2g/kg body weight for 7 days) helps to induce the Hepatotoxicity for the wistar albino mice. The effects of hepatoprotective were shown for both the dosage groups and it is highly active against the dosage of 400mg/kg ethanolic extract. Histopathological studies have confirmed there is no toxicity in liver tissue at both doses of 200 mg/kg and 400 mg/kg of ethanolic extract. The two different concentrations of ointment ethanolic extract (5% and 10%) Halymenia ceylanica were used to examine the wound-healing activity. It was observed that a 10% ointment of ethanolic extract had remarkable wound healing activity as evidenced by the significant increase in the rate of wound contraction, a decrease in the epithelium period and an increase in tissue tensile strength. The results imply that ethanolic extract of Halymenia ceylanica has the potential hepatoprotective and wound healing activity with the bioactive compounds of pharmacological relevance.