Strategies and mechanisms for enhancing drug bioavailability through Co-amorphous mixtures - A comprehensive review

Researchers started exploring the potential benefits of amorphous pharmaceuticals in the 1960s and 1970s, realizing that amorphous forms of drugs could have enhanced solubility and bioavailability. But to enhance the bioavailability the drug was needed to be made stable so the researchers started to study about combination of drugs (drug-drug, drug-excipients and Drug-Coformer). To formulate a Co-Amorphous (COAM) drug selection of best co-former is very necessary for increasing both the stability as well as solubility of the primary drug. Here in this review, I have mentioned various methods for preparation or formulation of Co-Amorphous Drugs processes for solid state characterizations and other analytical techniques regarding the COAM formulation. The current review explores different strategies and mechanisms for enhancing the oral solubility of various drugs with the help of Co-Amorphous Mixtures.