Effectiveness of the nutritional content and bioactive compounds of Ajwa dates (Phoenix dactylifera L) against anti-mullerian hormone (AMH) levels: A review

This literature review aims to provide a thorough study of many studies about Ajwa dates, including their nutritional makeup and the existence of advantageous compounds for health. Moreover, the aim of this literature research is to collect information on the relationship between the chemical makeup of Ajwa dates and the levels of the anti-mullerin hormone. Analysis of the PI3K/Akt/Foxo3a pathway showed that Quercetin decreased the phosphorylation of a protein that stimulates cyclophosphamide-induced follicular activation in the ovary. Moreover, Quercetin prevents cyclophosphamide-induced apoptosis in early-growing and antral follicles, maintains the Anti-Mullerian Hormone secreted by these follicles, and quiescence of the primordial follicle pool, as determined by intranuclear Foxo3a staining. It can be concluded that Quercetin in Ajwa Dates can attenuate cyclophosphamide-induced follicle loss by preventing phosphorylation of members of the PI3K/Akt/Foxo3a pathway and maintaining anti-Mullerian hormone levels through reducing apoptosis in growing follicles. Thus, Quercetin is expected to increase fertility We find that quercetin from Ajwa dates can inhibit PI3K/Akt/Foxo3a pathway members from becoming phosphorylated, which in turn can prevent cyclophosphamide-induced follicle loss. Additionally, quercetin can maintain anti-Mullerian hormone levels by lowering apoptosis in expanding follicles. Quercetin is therefore anticipated to boost fertility. The PI3K/Akt/Foxo3a pathway members' phosphorylation may be inhibited by quercetin from Ajwa dates, which can subsequently stop cyclophosphamide-induced follicle loss. Quercetin also reduces apoptosis in growing follicles, which helps to sustain anti-Mullerian hormone levels. Thus, quercetin is expected to increase fertility.