1Department of Microbiology, Saveetha Medical College, Saveetha Institute of Medical and Technical Sciences, Thandalam, Tamilnadu
In the realm of natural compounds sourced from plants, there lies a treasure trove of potential for the development of cutting-edge therapeutic drugs. Whether harnessed in their unadulterated state or as meticulously extracted standardized forms, these compounds hold the key to unlocking novel therapeutic avenues. Delving into the specifics of a recent study, the bulb of Allium sativum emerged as a pivotal biomass source, yielding a plethora of invaluable substances upon extraction. Through the intricate process of column chromatography, bioactive compounds were meticulously isolated from the Allium sativum bulb, following a comprehensive analysis via GCMS of the crude extract. Subsequent evaluation of antibacterial efficacy utilizing the Kirby-Bauer disc diffusion method shed light on the potent properties of the extract. Furthermore, a detailed investigation into the downregulation of specific genes in Staphylococcus aureus was conducted using conventional PCR techniques, revealing promising insights into the extract’s antivirulent attributes. This groundbreaking study not only underscores the remarkable therapeutic potential of Allium sativum but also underscores the pressing need for further exploration into its antioxidant, anti-inflammatory, and anti-diabetic properties to pave the way for a myriad of future therapeutic applications.
Bioactive Compounds, Allium Sativum, Garlic, Antibacterial, MRSA
