Formulation and Evaluation of Rhamnolipids - Based Ternary Solid Dispersion System for Poorly Soluble Drug

The goal of the current study is to create and assess ACF tablets with ternary solid dispersed product. ACF is poor solubility and a member of BCS class II. Water-soluble polymers and a biosurfactant were included in the formulation of the ternary system to improve bioavailability and dissolution rate. By employing the solvent evaporation method to prepare hydroxyl propyl methyl cellulose (HPMC) K-100 and polyethylene glycol (PEG) 6000 as biosurfactants and polymers, apiece, binary and ternary solid dispersions were prepared and assessed for drug content uniformity and in-vitro dissolution studies. By using a direct compression approach, ternary solid dispersed product was combined with additional excipients to create ACF tablets. Pre- and post-compression parameters were assessed for prepared formulations. The optimized tablet formulations TSD3 and TSD6 demonstrated an in-vitro dissolving profile of 96.85% and 99.85%, respectively, at a pH buffer of 6.8. The prepared pills’ pre- and post-compression values fell between the designated permissible ranges. An increase in the solubility rate consistent with pure medication was seen in a dissolution investigation of the improved formulation TSD6. At room temperature, the improved formulation’s short-term stability remained constant. For improved dissolution rate, dose reduction, and bioavailability in the formulation of ACF tablets, the incorporation of surface-active biomolecules to the ternary solid dispersion system showed to be a suitable excipient.