Formulation and In vitro Assessment of Valsartan Immediate Release Tablets

Our research was to manufacture of rapid-release tablets containing valsartan (VA). Despite, VA has a high degree of water insolubility, which hinders its oral bioavailability. The tablets were formulated using different methods and excipients like Ac-Di-sol, starch, Avicel PH 101, and Povidone K30 (P.V.P K30). Assessments were conducted to measure weight variation, hardness, content, friability, disintegration, and in vitro dissolution. Some tablet formulations exhibited satisfactory characteristics and adhered to compendial standards. The dissolution studies demonstrated that Ac-Di-Sol, in conjunction with the binding of starch paste, resulted in a dissolution rate of valsartan from formula F8 that exceeded 91% after 10 minutes. The manufactured tablets were compared with commercially available Diovan® 160 mg tablets, Novartis Pharma and the improved formulation was subjected to a stability study. Kneading with starch paste may improve VA flowability and Ac-Di-sol increases the release of VA from the tablets.