Research Journal of Pharmacy and Technology
SCOPUS
  • Year: 2025
  • Volume: 18
  • Issue: 10

Stability Indicating RP-HPLC Method for Estimation of Voxelotor for the Treatment of Sickle Cell Disease

  • Author:
  • Amitkumar J. Vyas1, Drashti J. Gajjar1,*, Saurabh S. Ray1, Ajay I. Patel1, Ashvin V. Dudhrejiya1, Devang B. Sheth2, Ashok B. Patel2, Sunny R. Shah3
  • Total Page Count: 6
  • Published Online: Jan 6, 2026
  • Page Number: 4759 to 4764

1B. K. Mody Government Pharmacy College, Gujarat Technological University, Rajkot, India

2L. M. College of Pharmacy, Gujarat Technological University, Ahmedabad, India

3Government Pharmacy College, Gujarat Technological University, Gandhinagar, India

*Corresponding Author E-mail: drashtigajjar5577@gmail.com

Online Published on 06 January, 2026.

Abstract

A stability indicating method for estimation of Voxelotor in tablet dosage form was developed. The method was optimised for sufficient resolution between drug peak and degradant peak. For this mobile phase of (MeOH: H2O) was selected in the ratio (75:25). The method was stressed under various conditions such as Acid and Base hydrolysis, Oxidative, Photolytic, and Thermal degradation. The method showed maximum tolerance against acid hydrolysis and minimum tolerance against base hydrolysis. The method was validated according to ICH guidelines Q2(R1).

Keywords

Stability Indicating Method Development, Forced Degradation, Validation, Voxelotor, HPLC