Computational Screening of Platostoma palustre Metabolites for Anti-Inflammation Bioactivity in the Chronic Obstructive Pulmonary Disease Gene Dataset

Platostoma palustre, also known as Cincau (Indonesian) or Xiancao (Chinese), is a plant that has been used and consumed as an herb. Through several previous studies, the various therapeutic potentials of P. palustre have been revealed little by little. However, research related to its use in chronic obstructive pulmonary disease (COPD) particularly in its anti-inflammation bioactivity effect is still limited. So, we conducted this research as initial research to fill a little of the information gap. The study was conducted using a list of active compounds of P. palustre from existing research, and then different expressed genes (DEG) related to COPD were obtained from the Gene Expression Omnibus dataset and evaluated for their bioactivity. Then, the active compound with the highest anti-inflammatory bioactivity potential was docked with DEG to determine its binding affinity. The result shown, that the active compounds with the highest anti-inflammatory bioactivity found in P. palustre were brassinolide, D-(+)-trehalose, leukotriene B4, linolenic acid, and diosgenin. Meanwhile, the DEGs from the COPD dataset obtained are FN1, CDH2, NOS3, DNAH9, DNAH11, CACNA1H, CACNG4, TNC, BAI1, and DNAAF1. Several active compounds have high binding affinity for FN1, CDH2, and NOS3, which are expected to induce anti-inflammatory activity through the inhibition that occurs.