Comparison of Pancreatic Histopathological Features in Wistar Rats Induced with The Diabetogenic Agent Streptozotocin

This study aims to determine the comparison of pancreatic histopathological features in Wistar rats induced with graded doses of STZ, to determine the comparison of). The random blood sugar test (GDS) in Wistar rats induced with graded doses of STZ, and to determine the comparison of body weight in Wistar rats induced with graded doses of STZ. This research uses a laboratory experimental method with quantitative data, which involves a lot of numbers from data collection, interpretation of the data, and presentation of the results. Similarly, in the conclusion, the results of the quantitative research are accompanied by many images, tables, and graphs, and use primary data sources obtained directly by observing the research object and treating the research object, resulting in new data that is then re-tested through several stages of research. Based on the results of the hypothesis test and the discussion that has been conducted, it can be concluded that there are differences in body weight, blood sugar levels, and pancreatic histology in Wistar rats with graded doses. Based on the results of the one-way ANOVA statistical test, it is concluded that the administration of graded STZ doses affects body weight, random blood sugar levels, and the histopathological picture of the pancreas in the group of white rats. (Rattus Norvegicus). The first hypothesis proposed in this study is “It is suspected that there are differences in body weight, blood sugar levels, and pancreatic histology in Wistar white rats given graded doses of STZ.” This study successfully concluded that the administration of graded doses of STZ significantly affects body weight, random blood sugar levels, and the histopathological appearance of the pancreas.