A Review on Analytical Methods for Estimation of Abacavir

Human Immunodeficiency Virus (HIV) is the cause of AIDS (Acquired immune deficiency syndrome). HIV impairs the immune system and interferes with the body’s ability to fight off disease and disorder. Contact with contaminated blood, semen or vaginal secretions is how it spreads. Although there is no known cure, medications can control the infection and stop the disease from getting worse. The nucleoside reverse transcriptase inhibitor (NRTI) counterpart of guanosine, abacavir, is sold as abacavir sulphate. This substance lowers HIV viral loads and delays or prevents immune system from damage. This succinct analysis of abacavir exemplifies the discussion of analytical techniques used to investigate abacavir in bulk and different dosage forms such as UV spectroscopy, HPLC, HPTLC, UPLC, and LC-MS. This helps the researcher who is willing to work on this drug or on multidrug combinations including abacavir. They will get detailed information about the method development and validation of the same by ICH guidelines. This comprehensive evaluation takes a look at analytical methods that were published between 2008 and 2018 using different analytical techniques.