Development and Evaluation of Gastroretentive Mucoadhesive Captopril Tablets

Mucoadhesive controlled–release tablets enhance drug efficacy by regulating drug concentrations within the therapeutic window, facilitating targeted delivery to specific sites, achieved through the formulation of oral tablets incorporating captopril and mucoadhesive polymers such as Tamarind Seed Polymer, Blackgram, Sodium alginate, Chitosan, Hydroxy propyl methylcellulose and Sodium CMC. The polymer extraction process involved isolating mucilage using conventional methods. Various concentrations of the polymers were utilized to achieve sustained drug release spanning duration of 12hours.The tablets underwent assessment based on multiple parameters including drug content, thickness, hardness, pH of the surface, swelling capacity, mucoadhesive strength, washout time, and drug release. The dissolution profiles underwent various kinetic analyses to scrutinize the drug release pattern, revealing a diffusion mechanism for drug release. Notably, formulation F7, comprisingTSP and HPMC, demonstrated the highest bioadhesive strength of 50gm. additionally; it’s in vitro drug release reached 96.70% after12hours, characterized by a non–Fickian diffusion mechanism. Following storage at45°C/75% RH for three months, there were no notable changes detected in the drug content, adhesive properties, clearance rate, or dissolution behavior in vitro.