Research Journal of Pharmacy and Technology

Of all endocrine conditions, thyroid-related disorders are the most prominent. In contrast to hyperthyroidism, hypothyroidism is more prevalent in India. In thyroidology, clinical assessments have long been employed to aid in the identification of thyroid dysfunction.

To figure out how well Wayne's and Zulewski's score works in patients with hyperthyroidism and hypothyroidism.

A six-month prospective observational study with patients aged 10 to 30 was conducted out. Eight instances had hyperthyroidism and ninety-three cases had hypothyroidism out of the 101 cases that were evaluated. Patient demographic information, clinical history, and physical examination data were gathered. Using Zulewski's score and logistic regression analysis, the odds ratio and its significance for the prevalence of various signs and symptoms have been determined.

Out of 103 patients studied, 93 patients were having hypothyroidism and 8 patients with hyperthyroidism. The prevalence of Hypothyroidism, Subclinical hypothyroidism, Euthyroidism, Toxic hyperthyroidism, Equivocal and Euthyroidism were 10.7%, 40.9%, 49.5%, 37.5%, 50% and 12.5% by using clinical scoring index.

Clinical scoring index, Wayne's index and Zulewski's index are not in common use and as score can vary with the observer, but in careful monitoring and observation of the patients we can identify the thyroid disease and commonly seen certain sign and symptoms are not included in clinical scoring index. So, the diagnosis and interpretation of types of thyroid disorder were very difficult by using only the clinical scoring index.