Evaluation and Comparison of Salivary Malondialdehyde and Superoxide Dismutase Levels As Oxidative Stress Markers in Chronic Desquamative Gingivitis before and after Nonsurgical Periodontal Therapy – A Biochemical Study

Chronic desquamative gingivitis (CDG) is an inflammatory condition often linked to immune-mediated disorders. Oxidative stress plays a role in periodontal damage and can be assessed using salivary malondialdehyde (MDA) and superoxide dismutase (SOD). This study evaluates changes in these markers before and after nonsurgical periodontal therapy.

To assess and compare salivary MDA and SOD levels in CDG patients before and after nonsurgical periodontal treatment.

The study included 46 participants (23 CDG patients, 23 healthy controls). Salivary MDA and SOD levels were measured biochemically. CDG patients underwent nonsurgical periodontal therapy, and post-treatment samples were collected after 10 days. Data were analyzed using t-tests.

No significant changes were observed in MDA (p = 0.712) or SOD (p = 0.385) levels post-treatment. Additionally, no significant differences were found between CDG patients and healthy controls (MDA: p = 0.576, SOD: p = 0.333).

Nonsurgical periodontal therapy had no significant effect on oxidative stress markers in CDG. Oxidative stress levels in CDG patients were comparable to healthy individuals, indicating a limited role in disease progression.

These findings highlight the need for further research into alternative therapeutic strategies for managing CDG.