Department of Chemistry, Kanya Gurukul, Gurukula Kangri (Deemed to be University), Haridwar - 249407, Uttarakhand, India
*Corresponding Author E-mail: palakkansal24@gmail.com
Online Published on 15 May, 2025.
The purpose of this research was to explore the potential anti-diabetic and anti-inflammatory effects of green solvent extracts obtained from Ficus drupacea leaves. Additionally, the study highlights the safety and viability of green solvents as alternatives to organic solvents.
The study employed a sequential extraction process using Soxhlet extraction technique with increasing polarity of solvents i.e., dimethyl carbonate, isopropyl alcohol, hydro alcohol (ethanol: water - 60:40) and water. The dried concentrated extracts were then analyzed for their anti-diabetic and anti-inflammatory activities through standard in-vitro techniques. The investigation included an in-vitro approach i.e., heat-induced denaturation of bovine serum albumin (BSA) to determine the anti-inflammatory properties while α-amylase and α-glucosidase assays were used to assess the extracts for anti-diabetic activity. Reference drugs such as diclofenac sodium and acarbose were used for the comparison.
Among the various green solvent extracts (dimethyl carbonate, isopropyl alcohol, hydro alcohol and water extracts), hydroalcoholic extract of Ficus drupacea leaves exhibited significant anti-inflammatory and anti-diabetic properties.
The findings of this study demonstrate the significant anti-inflammatory and anti-diabetic effects of Ficus drupacea leaves in in-vitro models.
Ficus drupacea, Dimethyl carbonate, Isopropyl alcohol, Hydro alcohol, Water, Anti-diabetic activity, Anti-inflammatory activity
