*Corresponding Author E-mail: samalpharmacology@rediffmail.com
The purpose of this study was to evaluate the hepatoprotective properties of Lathyrus sativus leaves against liver damage caused by paracetamol in Wistar rats.
Rats with hepatotoxicity from paracetamol were utilised to test the hepatoprotective benefits of a methanol extract made from Lathyrus sativus leaves. To cause hepatotoxicity, albino Wistar rats were fed paracetamol (2 g/kg) orally for 14 days. For 14 days, oral administration of the Lathyrus sativus leaf methanol extract at 200 and 400 mg/kg/day was conducted. The quantities of albumin, total bilirubin, ALT, AST, ALP, and protein were found using a serum analysis. To measure the amounts of glutathione, malondialdehyde, and superoxide dismutase, the liver was removed and ground up. Furthermore, investigations related to histology were performed on the liver samples.
The groups who received extract treatment were able to reduce the negative effects of paracetamol while restoring blood biochemical parameters to levels that were nearly normal.
According to the study, Lathyrus sativus leaves have significant hepatoprotective effects.
Paracetamol, Hepatoprotective activity, Lathyrus sativus, Oxidative stress, Antioxidant
